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The dosing schedule in those studies differ from the dosing schedule that your physician may recommend. As a result of this dosing differential, your results may vary depending on your weight, BMI, diet, activity level, dose of Qsymia, and other factors. For the subjects in the 2 studies the average baseline weight was lbs and lbs, and the average baseline waist circumference was 47 inches and 45 inches.

The chart presents data for patients who completed treatment at each time point. Some patients left the study or stopped taking Qsymia prior to completing the full 56 weeks. Analysis of all patients including those who dropped off results in slightly smaller reductions in weight and waist circumference. Weight loss in all patients was 4. The reduction in waist circumference was 1.

Patients who can become pregnant should have a pregnancy test before taking Qsymia and every month while taking Qsymia and use effective birth control contraception consistently while taking Qsymia. Talk to your healthcare provider about how to prevent pregnancy. If you become pregnant while taking Qsymia, stop taking Qsymia immediately, and tell your healthcare provider right away. Qsymia can increase your heart rate at rest.

Your healthcare provider should check your heart rate while you take Qsymia. Tell your healthcare provider if you experience, while at rest, a racing or pounding feeling in your chest lasting several minutes when taking Qsymia. In clinical trials, most of these events were reversible after topiramate discontinuation.

If visual problems occur at any time during treatment, consider discontinuing Qsymia. Suicidal thoughts or actions. Topiramate, an ingredient in Qsymia, may cause you to have suicidal thoughts or actions. Serious eye problems, which include any sudden decrease in vision, with or without eye pain and redness or a blockage of fluid in the eye causing increased pressure in the eye secondary angle closure glaucoma.

These problems can lead to permanent vision loss if not treated. Tell your healthcare provider right away if you have any new eye symptoms. Qsymia may cause a severe rash with blisters and peeling skin, especially around the mouth, nose, eyes, and genitals Stevens-Johnson Syndrome. Qsymia may also cause a rash with blisters and peeling skin over much of the body that may be life threatening Toxic Epidermal Necrolysis.

Numbness or tingling in the hands, arms, feet, or face paraesthesia ; dizziness; changes in the way foods taste or loss of taste dysgeusia ; trouble sleeping insomnia ; constipation; and dry mouth. Mood changes and trouble sleeping. Qsymia may cause depression or mood problems, and trouble sleeping. Tell your healthcare provider if symptoms occur. Concentration, memory, and speech difficulties. Qsymia may affect how you think and cause confusion, problems with concentration, attention, memory or speech.

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