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Topiramate is an oral antiepileptic drug AED used for partial-onset, generalized primary tonic-clonic seizures, and as an adjunct therapy in Lennox-Gastaut syndrome. It is derived from the naturally occurring monosaccharide D-fructose and is structurally different phentermine topiramate price other AEDs. Topiramate possesses more than one mechanism of action, which may explain why it can be effective in patients with various seizures that are refractory to other agents.
Every month of the simulation, patients could either continue receiving treatment or permanently discontinue treatment. Patients receiving lifestyle counseling adjunct to an antiobesity medication could experience an adverse event every month. Monthly change in body mass index was dependent on the specific treatment strategy, and all patients experienced weight gain after discontinuing any treatment. Death was determined from age- and sex-specific mortality rates. Model parameters were independently varied across a set range while all other parameters were held constant at their mean value. The horizontal bars represent the range of incremental net monetary benefit when changing the value of each model parameter, and the color indicates which strategy was preferred.
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Authored by Dr. Dawn Peterson, MD