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Oral vitamin A might serve as an alternative to isotretinoin for the management of patients with severe acne although there is a need for more up-to-date and rigorous clinical trials. Systemic isotretinoin which is an oral derivative of vitamin A is the most effective treatment for both severe acne and for moderate severity disease that is unresponsive to other treatment modalities. Moreover, oral vitamin A was associated with the same mucocutaneous side-effects such as xerosis and cheilitis and serious adverse effects such as teratogenicity is also a known problem. Oral vitamin A for acne management: a possible substitute for isotretinoin J Drugs Dermatol Dismayed reactions from sector over proposed GPhC fees increase.

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Accutane is derived from Vitamin A, which has been used to fight acne since Different companies have developed numerous Vitamin-A based acne treatments over the years, including retin-A, isotretinoin and Accutane. Before the release of Accutane, severe acne was primarily treated with oral antibiotics like tetracyclines and erythromycin. While these buys accutane eu worked for some patients, they were only effective against one of the bacteria that cause acne, Propionibacterium. Over time, these antibiotics grew less and less effective as the bacteria developed more resistant strains. Another early method of treating acne was to use high doses of fat soluble vitamin A.

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