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Isotretinoin is a chemical derivative of Vitamin A. How effective is Isotretinoin? Isotretinoin has been available for use for nearly thirty years. No other drug has proven as effective in the management of acne and it is unlikely in the foreseeable future that any other drug will become available which is as effective over time. How we use the medication has changed. It has been a trend over recent years to reduce the daily dose of the drug, thus limiting the side effects.